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مقاله
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Abstract
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Title:
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The effect of short course consumption of low dose isotretinoin on tear film function
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Author(s):
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Dr. M. R. Rohani, MD, Dr.S.A.moosavi, , Dr.H.khallaghi
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Mohammad reza Rouhani
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Affiliation :(optional)
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zahedan university of medical sciences
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E mail:
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dr_mr_Rohani@yahoo.com
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Phone:
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0541 2417337
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Mobile:
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09151411877
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Purpose:
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To evaluate the tear film function and refractive conditions during and one month after treatment of acne vulgaris with isotretinoin (Accutane)
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Methods:
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This prospective study was performed on 26 eyes of 13 known cases of acne vulgaris. All cases were referred by a dermatologist and were candidates for low dose isotretinoin (0.5 mg/kg). Full anterior and posterior segment examination, objective and subjective refraction were conducted. Tear film function was assessed by the anesthetized schirmer test, tear breakup time (TBUT) and tear osmolarity test before, during and after treatment with systemic isotretinoin.
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Results:
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: No significant difference was observed in BCVA and refractive conditions in patients before, during, or after systemic isotretinoin prescription. Increased TBUT results were obtained in 2 and 3 patients during and one month after medication respectively which was not significant. Anesthetized schirmer showed a significant decrease during treatment (p=0.013). However this trend did not remain significant after drug cessation (p=0.783). On the other hand, tear film osmolarity showed a significant increase during (303.91±15.71osm/L) (p< 0.05) and even one month after drug discontinuation (312.75 ±28.39osm/L) (p= 0.01).
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Conclusion:
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this study showed that isotretinoin can lead to permanent alterations in tear film condition
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Attachment:
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