This study was designed to investigate the indications for corneal transplantation in shahid sadooghi medical university as a referral hospital in yazd province.

this is a retrospective descriptive study that all case which undergo corneal transplantation were included. There were totally 351 corneal transplant surgeries done through the period

Of the 351 cases , 203 (57.8%) were male and 148(42.2%) were female. In this study keratoconus was the most common indication for keratoplasty with the prevalence of 41.3%. it was more common in males than females. Corneal opacity and scar was the 2th common indication for keratoplasty. It accounted for 25.1 % of all indications. In most cases the cause of corneal opacity was not specified. Psudophakic corneal edema was the 3th common indication for keratoplasty. It accounted for 8.3% of all indications. The important point was the fact that most of the psudophakic patients were older than 60 years old. Regraft was the next common indication and accounted for 6.8% of indications.. The most common cause for regraft was corneal opacity and scar. Corneal dystrophy was the 5th common indication for corneal transplantation and accounted for 6.2% . macular corneal dystrophy and fuchs endothelial dystrophy were the most common dystrophies,respectively. Corneal perforation was a less common indication and accounted for 5.4% of all indications. The most common cause of corneal perforation was bacterial ulcer. Aphakic corneal edema was the least common indication for keratoplasty and accountes for just 2.3%.

As a conclusion keratoconous remain the leading indication for corneal transplantation in our center.