To introduced differential diagnosis of lesions that were misdiagnosed as pseudoretinoblastoma.

The data of patients, referred to Farabi Eye Hospital oncology clinic between Jan 2009 and July 2013 with the diagnosis of retinoblastoma were evaluated from medical records. The examination under general anesthesia was performed for each patient. The other investigation like ultrasonography was done if needed.

331 patients (age range of 1-60 month) were referred to our Hospital by suspected diagnosis of retinoblastoma. The rate of misdiagnosis was 42% that consisted of Coats disease (36), PHPV or persistent hyperplastic primary vitreous (31), Familial Exudative Vitreoretinopathy (FEVR )(14), chorioretinal coloboma (10), self controlled retinopathy of prematurity (ROP) (10), non attachment of retina (6), combined hamartoma (5), TORCH (5), Astrocytoma (4), Congenital cataract (2), Organized vitreous hemorrhage (2), Acute lymphocytic leukemia (1), Asteroid hyalosis (1), Astrocytic hamartoma (1), Congenital retinal fold (1), Medoloepithelioma (1), Juvenile rheumatoid arthritis (1), Incontinentia pigmenti (1), Myelinated retinal nerve fiber layers (1), Morning glorry syndrome (1), Norrie's disease (1), Retinocytoma (1), Toxocariasis (1), Prepthysic eye (1).

The wide ranges of lesions may mimic retinoblastoma that could be differentiated by exact examination and ocular imaging.