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       XXIII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و سومین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Evaluation of topical bevacizumab as an adjunct to mitomycin C augmented trabeculectomy
Author(s): M Masoumpour MD. R Zarei MD. S Moghimi MD. G Fakhraei . Y Eslami MD.
Presentation Type: Oral
Subject: Glaucoma
Others:
Presenting Author:
Name: Masoumeh beigom Masoumpour
Affiliation :(optional) Farabi Eye Research Center, Tehran University of Medical Sciences
E mail: masoumpour@yahoo.com
Phone: 0711 8450518
Mobile: 09173122605
Purpose:

To investigates the safety and synergistic effect of topical bevacizumab after trabeculectomy with mitomycin C.

Methods:

In this prospective, non-randomized, interventional study 32 patients with uncontrolled open angle glaucoma were underwent trabeculectomy with mitomycin C. Topical bevacizumab (4 mg/mL) was used for following 2 weeks 4 times daily in 16 eyes (group A). The outcome measures were the intraocular pressure (IOP), number of medications, complications and bleb evaluation.

Results:

The mean preoperative IOP in the group A improved from 26.7 ± 9.3 mm Hg with 2.8 medications to 10.5 ± 2.8mm Hg with 0.7 medications at last follow-up (P < 0.001). The mean preoperative IOP in the group B improved from 21.8 ± 6.6 mm Hg with 3.1 medications to 11.4 ± 3.6 mm Hg with 0.8 medications at last follow-up (P < 0.001). Cystic type of bleb was less common in the group A (P= 0.043). A patient in group A developed streptococcal corneal ulcer.

Conclusion:

Administration of topical bevacizumab 4mg/ml for two weeks following trabeculectomy with mitomycin C was not found to significantly affect the intraocular pressure trend, but significantly decrease the cystic bleb formation in short-term follow-up.

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