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مقاله
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Abstract
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Title:
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Physical,biological chemical stability,sterility of fortified ophthalmic antibiotics stored at 4 , 24 degree for 0 , 4 , 7 , 14 , 28 days after reconstituted in varies solution
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Author(s):
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Hamid Gharaie, Kiarash Ghazvini , Fateme Rahimi ,Habib Jafafri
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Presentation Type:
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Poster
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamid Gharaee
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Affiliation :(optional)
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eye research center,Mashhad University of Medical Sciences
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E mail:
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gharaee_oph@yahoo.com
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Phone:
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8456918
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Mobile:
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09151117976
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Purpose:
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We investigate the stability and antibacterial potency of fortified solutions of vancomycin , amikacin, cefazolin and ceftazidim prepared in 4 diluents.
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Methods:
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The solutions with vancomycin 5% amikacin 2% ceftazidim 5% cefazolin 5% antibiotics reconstructed in BSS DW 5% sodium chloride were evaluated at o,4,7,14 and 28 days after preparation in terms of osmolarity PH and MIC
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Results:
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There was no significant differences in MIC of vancomycin within 4 weeks period but MIC was amikacin, ceftazidim was change after 7 days in 2 temperature. PH osmolarity of solutions was stable for 4 weeks in 2 temperature but cefazolin was not stable osmolarity of snow tears was higher than BSS , sodium chloride , DW 5% and higher than level of normal tear films.
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Conclusion:
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Vancomycin in BSS DW5% can be safely used for 4 weeks we recommended BSS sodium chloride for amikacin and should be discard after 1 week in 4c and 24c cefazolin was recommended in DW5% and sodium chloride should be discard after 1 week in 4 c and 24c DW5% sodium chloride was recommended for ceftazidim and stored in 4c
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Attachment:
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635.pptx
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