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مقاله
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Abstract
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Title:
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Sensitivity and Specificity of Posterior and Anterior Corneal Elevation Measured by Orb Scan in Diagnosis of Clinical and Subclinical Keratoconus
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Author(s):
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Jafarinasab MR, Shirzadeh E, Feizi S ,Akaberi A, hasanpoor H
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Ebrahim Shirzadeh
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Affiliation :(optional)
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Associate Professor of Ophthalmology Sabzevar University of Medical Sciences, Sabzevar, Iran and cornea fellowship of Shahid Beheshti University of Medical Sciences, Tehran, Iran
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E mail:
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dreshirzad@yahoo.com
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Phone:
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05712642672
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Mobile:
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09155723537
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Purpose:
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To estimate the sensitivity and specificity of anterior and posterior corneal elevation in discriminating Subclinical and clinical Keratoconus (KCN) from normal corneas.
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Methods:
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Both anterior and posterior corneal elevation in Subclinical and clinical KCN were compared with that in normal corneas in separate analyses. Receiver operating characteristic (ROC) curves were used to identify optimal anterior and posterior corneal elevation cutoff points.
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Results:
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study was carried out on 28 eyes with subclinical KCN, 65 eyes with clinical KCN, and 141 eyes with normal corneas. Mean anterior and posterior corneal elevation in KCN and subclinical KCN versus normal cornea were statistically higher. ROC curve of posterior corneal elevation showed that optimal cutoff points were 51 µm for KCN and 35 µm for subclinical KCN with sensitivity and specificity of 89.23% and 98.58 %, respectively, for KCN; 50.00 % and 88.65% for subclinical KCN. ROC curve analyses of anterior corneal elevation showed that optimal cutoff points were 19 µm for KCN and 16 µm for subclinical KCN with sensitivity and specificity of 93.85% and 97.16 %, respectively, for KCN; 60.71% and 87.94% for subclinical KCN.
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Conclusion:
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Anterior and posterior corneal elevation data measured by the Orbscan II are very effective for discriminating KCN from normal cornea but efficacy is some lower for detecting subclinical KCN from normal cases.
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Attachment:
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