|
مقاله
|
Abstract
|
|
|
|
Title:
|
Evaluating therapeutic effect of topical and intrastromal Voriconazol and topical Natamycin on fusarium keratitis in rabbit
|
|
Author(s):
|
Mahmoud Nejabat, Amir Khosravi, Nafiseh Yaghoubi
|
|
Presentation Type:
|
Oral
|
|
Subject:
|
Cornea and Anterior Segment
|
|
Others:
|
|
|
Presenting Author:
|
|
|
Name:
|
Amir Khosravi
|
|
Affiliation :(optional)
|
poostchi ophthalmology research center, shiraz university of medical sciences
|
|
E mail:
|
Amir11khosravi@gmail.com
|
|
Phone:
|
|
|
Mobile:
|
09177100900
|
|
|
|
|
Purpose:
|
To evaluate the therapeutic effect of topical and intrastromal Voriconazol and topical Natamycin on fusarium keratitis.
|
|
Methods:
|
24 rabbits were selected. The stroma of their corneas were inoculated with suspension of Fusarium solani. 7 days after injection they were divided into 4 groups randomly: the first group was treated with topical Voriconazol(TV) 1% for one week, the second one with one time intrastromal injection of Voriconazol(ISV) 50µgr/0.1ml, the third group with topical gel of Natamycin(TN) for one week, and the last one did not receive any antifungal treatment. Finally the eyes were enucleated and sclerocorneal buttons were sent for histological and microbiological examinations.
|
|
Results:
|
After treatment the (ISV)group and (TN)group showed significant lower clinical score and colony diameters than control group (P=0.040 and P=0.026), but there was statistically no significant difference between control and (TV)group (P=0.249) or between (ISV) and (TN)group (P=0.665). In pathological evaluation, fewer chronic inflammations were reported in 2 of the 3 buttons from (TV)group and 3 of the 3 buttons from (ISV) and (TN)group in comparison with control group.
|
|
Conclusion:
|
Intrastromal injection of voriconazole seems to be effective in treatment of fusarium keratitis as much as topical natamycin and these are more effective than topical voriconazol.
|
|
Attachment:
|
|
|