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مقاله
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Abstract
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Title:
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Viral vectors for gene therapy in ocular diseases : a tutorial abstract
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Author(s):
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Maryam Esghaei a, Seyed Hamid Reza Monavaria, Farah Bokharaei-Salima , Z-azita Sadighb
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Presentation Type:
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Poster
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Maryam Esghaei
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Affiliation :(optional)
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Department of Virology, Iran University of Medical Sciences, Tehran, Iran
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E mail:
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m-esghaei@tums.ac.ir
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Phone:
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22525538
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Mobile:
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09127132859
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Purpose:
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Gene therapy have progressed for a variety of retinal disorders, including retinitis pigmentosa,retinoschisis, Stargardt disease and age-related macular degeneration.This abstract explains current processes and future prospects at novel methods for ocular genetherapy to enhance the efficiency of adeno-associated virus- and lentivirus-mediated ocular gene transfer.
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Methods:
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Adeno-associated virus (AAV) vectors are suited for uses in chronic ocular because exist instead as extragenomic episomes, notably decreasing the risk of insertional oncogenesis. AAV-mediated retinal gene therapy may be successfully extended to blinding conditions. They extract minimal immune responses and allow for stable, long-term transgene expression in a diversity of retinal cells, including photoreceptors,retinal pigment epithelium (RPE) cells, ganglion cells and many types of neurons.Adenoviral (Ad) vectors, like AAV vectors, are non-integrating and transduce both dividing and non-dividing cells.
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Results:
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Lentiviral vectors can induce stable, long-term transgene expression in anterior ocular structures, including the corneal endothelium and the trabecular meshwork. Because they are integrating vectors, certifiable interests have been raised over the risk of insertional oncogenesis.
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Conclusion:
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Unco progress the confirmation of proof-of implication for gene therapy approaches targeting a variety of formerly unknown conditions, gene therapy may indeed be an basic treatment strategy for ocular diseases in the near future.
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Attachment:
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