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مقاله
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Abstract
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Title:
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Electrophysiological and Histological Changes in Retinal Pigmented Epithelium after Injection of Sodium iodate in Retro- orbital sinus of Pigmented Rat
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Author(s):
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Hamid Abootaleb,Taki Tiraihi, Hamid Ahmadieh, HoseinziaiiArdakani, NarsisDaftaryian
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Presentation Type:
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Poster
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Hamid Aboutaleb Kadkhodaeean
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Affiliation :(optional)
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Shefa neuroscience research center ,Khatam-Al-Anbia Hospital, Tehran, Iran
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E mail:
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habootaleb92@gmail.com
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Phone:
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Mobile:
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09377711768
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Purpose:
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INTRODUCTION:We characterized changes in the visual behavior of pigmented rat in which a loss of the retinal pigment epithelium (RPE) was experimentally induced with retro-orbital venous plexus administration of sodium iodate (NaIO3).We compared and correlated these changes with alterations in neural retinal structure and function
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Methods:
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METHODS:RPE loss was induced in 250g pigmented rat with an retro- orbital sinus injection of 1% NaIO3 at threeconcentrations: 40, 60 mg/kg. At 1, 7, 14, 21, and 28 days (d) post injection (PI) a behavioral test was performed to evaluate visual function.Eye morphology was then assessed for changes in both the RPE and neural retina
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Results:
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RESULTS:NaIO3-induced RPE degeneration was both dose and PI time dependent. Our low dose showed effects, while our high dose caused the most damage. at 3 d PI visual behavior became abnormal and patchy RPE cell loss was observed. From 7 d PI onward, changes in retinal morphology and visual behavior became more severe
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Conclusion:
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RESULTS:NaIO3-induced RPE degeneration was both dose and PI time dependent. Our low dose showed effects, while our high dose caused the most damage. at 3 d PI visual behavior became abnormal and patchy RPE cell loss was observed. From 7 d PI onward, changes in retinal morphology and visual behavior became more severe
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Attachment:
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757sample(1).pptx
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