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مقاله
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Abstract
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Title:
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Monosomy 3 by Chromogenic In Situ Hybridization (CISH) in Iranian Patients with Uveal Melanoma
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Author(s):
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Masood Naseripour MD1, Mitra Mehrazma MD2, Rama Pourmatin MD1, Mohsen
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Presentation Type:
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Oral
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Masood Naseripour
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Affiliation :(optional)
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Eye Research Center,Rassoul Akram Hospital,Ophtahlmology Department, Iran University of Medical sciences. 2)2. Oncopathology Research Center,Rassoul Akram Hospital, IUMS
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E mail:
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masoodnp@yahoo.com
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Phone:
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66509162
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Mobile:
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09123274983
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Purpose:
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The aim of study was to investigate the rate of monosomy 3 by CISH technique in Iranian patients with uveal melanoma (UM) and its correlation with clinical and histopathological features
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Methods:
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Archival formalin fixed, paraffin embedded material from 50 patients who had undergone enucleation for large uveal melanomas was obtained. Monosomy chromosomes 3 alteration by chromogenic in situ hybridization(CISH) was investigated. Clinical and histopathological features of tumors were collected.
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Results:
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The patients had a mean age of 56.6 years. Mean basal diameter and thickness of tumors was 14.1 mm and 10.2 mm respectively. Four patients (8%) were identified to harbor monosomy of chromosome 3. In mean follow up of 5.3 years (range, 3.2 –9.5 y) only one of our cases with monosomy 3, died of UM metastasis. The most common type of cellularity was mixed cell(86%). There was not any statistically significant correlation between monosomy of chromosome 3 and type of cellularity , ciliary body involvement and largest basal diameter.
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Conclusion:
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Lower rate of monosomy chromosome 3 and the consequent decrease in mortality may be indicative of good prognosis in Iranian patients with uveal melanoma.
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Attachment:
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