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مقاله
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Abstract
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Title:
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AMD genetics
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Author(s):
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reza karkhaneh, aliasghar ahmadraji, mohammad riazi esfahani
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Presentation Type:
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Oral
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Aliasghar Ahmadraji
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Affiliation :(optional)
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E mail:
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hamidraji2000@yahoo.com
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Phone:
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02122829716
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Mobile:
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09122878096
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Purpose:
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To evaluate the frequency of 12 single nucleotide polymorphisms of complement factor H and LOC387715/ARMS2/HRTA1 and interaction of them with some of the clinical features of neovascular AMD
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Methods:
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forty four patients with neovascular age related macular degeneration were genotyped using sequencing technique
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Results:
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Tmost frequent SNP was rs1061147 with 98.08% frequency rate . The least common was rs2672598 with frequency of 44.23%.Only the allele rs800292 was associated with better visual acuity , p value 0.034 . The frequency of this allele was 65%(29 patients ) . There was not any significant correlation between any of alleles and worse VA.Also there was not any significant association between any of SNPs and bilaterality of disease
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Conclusion:
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We have found frequencies of SNPs of CFH and LOC387715/ARMS2/HRTA1 in neovascular AMD in Iranian patients .Only the allele rs800292 of CFH locus on 1q32 was associated with better visual acuity
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Attachment:
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