Vernal keratoconjunctivitis (VKC) is a chronic ocular allergy disease, which is observed predominantly with complaints of severe itching and photophobia accompanied by ocular discomfort and lacrimation, resulting in visual disturbances. The trial was designed to evaluate the efficacy and safety of topical honey eye drops in patients with diagnosed VKC.

In this clinical trial was conducted on 60 patients with diagnosed VKC. The patients were selected and consecutively designated in to two groups of 30. Patients in two groups received Honey eye drop (60% in artificial tear) or placebo, other than Cromolyn and Fluorometholone 1% eye drops to be used topically in each eye four times per day. Patients were examined with slit lamp and torch at baseline and follow-up visits on the 1st, 3rd and 6th months of the study for redness, limbal papillae, intraocular pressure and visual acuity.

Out of 60 patients who completed the study, 19 patients (31.7%) were female. Visual acuity in both left and right eyes were significantly increased after study. There was a significant reduction in redness and limbal papillae, following the consumption of the honey drop in group compared to placebo control group (P<0.05). At the end of trial one patient in honey group and 7 in placebo group had limbal papillae (P<0.05).

Topical honey eye drops, when used along with Cromolyn and Fluorometholone eye drops might be beneficial for the treatment of VKC.