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مقاله
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Abstract
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Title:
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Corneal biomechanical properties at different collagen cross-linking (CXL) fluences
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Author(s):
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Arthur Hammer, MD; Samuel Mosquera, PhD; Olivier Richoz, MD; David Tabibian, MD; Florence Hoogewoud, MD; Farhad Hafezi, MDPhD
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Arthur hammer Hammer
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Affiliation :(optional)
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Geneva University Hospitals
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E mail:
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arthur.hammer6@gmail.com
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Phone:
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Mobile:
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+41 76 365 96 09
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Purpose:
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CXL devices recently started using higher fluences and lower irradiation time, keeping the total energy constant according to the Bunsen-Roscoe law and assuming that the increase in biomechanical stiffness will remain the same. However, no clinical data is available to support this hypothesis
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Methods:
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We investigated the biomechanical properties of porcine corneas in 4 groups (n=16): 3 groups were exposed to riboflavin 0.1 % and to UVA irradiation at 3, 9 and 18 mW of intensity with an exposition time of 30, 10 and 5 minutes respectively. Controls were only exposed to riboflavin 0.1 %. Corneal strength was determined using a Zwick extensometer
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Results:
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We observed significant differences between 3 mW/cm2 and 9 mW/cm2, 18 mW/cm2 and the control group(p = 0.004, p = 0.024 and p = 0.001 respectively) for the Young’s modulus at 10 % of strain
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Conclusion:
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The biomechanical effect of CXL seems to decrease to a significantly lower level when using the high fluence/short irradiation time settings, rising concerns about the clinical efficiency of the new CXL devices appearing on the market. Intrastromal oxygen diffusion capacity might be a limiting factor, correspondingly increased oxygen consumption associated to higher fluence may lead to reduced treatment efficiency
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Attachment:
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