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مقاله
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Abstract
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Title:
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The ocular hypotensive effect of saffron extract in primary open-angle glaucoma: a pilot study
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Author(s):
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Mohammad Hossein Jabbarpoor Bonyadi , Shahin Yazdani, Saeed Saadat .
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Presentation Type:
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Oral
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Mohammadhossein Jabbarpourbonyadi
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Affiliation :(optional)
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Department of Ophthalmology, Gonabad University of Medical Sciences, Gonabad, Iran and Center of Excellence for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
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E mail:
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mhbonyadi@yahoo.com
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Phone:
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05337226999
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Mobile:
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09144170912
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Purpose:
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To evaluate the effect of aqueous saffron extract on intraocular pressure (IOP) in primary open-angle glaucoma (POAG).
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Methods:
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Thirty-five eyes of 35 patients with POAG under treatment with topical timolol and dorzolamide, were randomized to receive 30 mg/d aqueous saffron extract for one month (17 eyes) While the other 18 eyes served as the control group. Following the treatment period, both groups entered a one-month wash-out period. Main outcome measure was IOP during treatment period and after the wash-out period.
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Results:
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Mean baseline IOP before intervention was 14.23±3.49 mmHg in the saffron group versus 15.72±2.27 mmHg in the control group (p=0.149). After three weeks of treatment, IOP was significantly decreased to 12.35±3.44mmHg in the saffron group as compared to 15.22 ± 2.18mmHg in the control group (p=0.007). At four weeks, IOP was significantly lower in the saffron group (11.94±3.15 mmHg versus 15.50±1.917 mmHg in the saffron and control groups respectively, p=0.0004). At the end of the wash-out period, IOP was 14.29±2.77 in the saffron group and 15.83±1.75 mmHg in the control group (p=0.06).
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Conclusion:
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Oral aqueous saffron extract seems to have ocular hypotensive effect in POAG. This effect became evident after three weeks of therapy.
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Attachment:
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