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مقاله
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Abstract
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Title:
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Topical Interferon Alpha-2b for the Treatment of Non-invasive Ocular Surface Squamous Neoplasia with 360-Degree Limbal Involvement
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Author(s):
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Siamak Zarei-Ghanavati1, MD, FICO; Reza Alizadeh1, MD; Sophie X. Deng2, MD, Ph.D
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Siamak Zarei ghanavati
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Affiliation :(optional)
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Mashhad University of Medical Sciences (MUMS)
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E mail:
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sizagh@yahoo.com
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Phone:
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0511-7659461
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Mobile:
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09151153024
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Purpose:
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To report the results of topical interferon alpha-2b (IFNα2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360-degree limbal involvement.
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Methods:
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In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360-degree limbal involvement received topical IFNα2b (3 million IU/ml, 4 times daily) and followed between 8 to 12 months. Outcome measures included resolution of CIN, symptoms recovery, systemic and ocular side effects and the recurrence rate.
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Results:
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Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha-2b. The mean age was 60.2 years (range: 52-73 years). The mean follow up was 10.2 months. Clinical resolution of the tumor occurred in all cases 2 months after the initiation of treatment and no patient developed ocular or systemic complication. No OSSN recurrence developed during the follow up.
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Conclusion:
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Topical recombinant IFNα2b appears to be a safe and effective treatment for OSSN with 360-degree of limbal involvement without a high risk of limbal stem cell deficiency associated with surgical excision or topical chemotherapeutic agents.
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Attachment:
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