Bevacizumab (Avastin) seems to be increasing in management of Clinically Significant Macular Edema(CSME) , Choroidal neovascularisation, Central retinal vein occlusion (CRVO), Branch Retinal Vein Occlusion(BRVO) and so on. Endophthalmitis is a catastrophic event that may occurred after Bevacizumab injection. This article specially focused on a method of avastin injection and report the rate of post injection endophthalmitis.

This study includes evaluation of charts of 250 patients that scheduled for avastin injection in a center affiliated to shiraz university of medical sciences between December 2010 to December 2012. Injections were done by one surgeon and method of injection consists of applying one drop tetracaine, After that we applied a drop consists of 5 ml Ciprofloxacine and 5 ml Bethdine5% for 3 times with intervals of 10 minutes. 250 mg Acetazolamide parentrally was used by patients 30 minutes before injection. After prep the eye with Bethadine solution 10%, Injection was done 3.5-4 mm from the limbus. Ciprofloxacin eye drop every hour for first 24 hours and every 4 hours for 5 days started for patients. One day after injection patients evaluated for any sign of endophthalmitis.

There were 147(58.8%) female and 103(41.2%) male in this study population.The mean age of the patients was 60.1 ± 13.7 years. Diagnosis of patiens consisted of CSME 138(55.2%) , CNV 63(25.2%) , CRVO 36(14.4%) , BRVO 13 (5.2%). The total number of injections was 1140 with mean 4.56 injections. Right eye injection 508(44.6%) and left eye injection 632(55.4%). In these patients, no any endophthalmitis was seen.

After 1140 injections we did not have any endophthalmitis . It seems that our method of injection can be a safe method for intravitreal injection. The commonest cause for injection in our study was CSME