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مقاله
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Abstract
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Title:
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The Role of Amniotic Membrane Transplantation in Severe Ocular Chemical Burn
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Author(s):
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Alireza Baradaran-Rafii, MD; Hamidreza Hasani, MD; Medi Eslani, MD; Mohammad-Hossein Jabbarpoor-Bonyadi, MD; Mostafa Naderi, MD
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamid reza Hasani
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Affiliation :(optional)
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Ophthalmic Research Center, Labbafinejad Medical Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran
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E mail:
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hamidrezahasani@yahoo.com
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Phone:
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02122550483
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Mobile:
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09121759054
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Purpose:
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To evaluate the effect of Amniotic Membrane Transplantation in the management of acute severe ocular chemical burns.
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Methods:
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This randomized clinical trial was performed in eligible patients with grade III& IV acute chemical burn randomly received conventional medical therapy( 15 eyes) versus combined medical & amniotic membrane transplantation (15 eyes). Main outcome measures were corneal epithelial healing time and improvement in perilimbal ischemia. Secondary outcome measures included visual acuity, corneal transparency , vascularization, symblepharon formation and complications.
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Results:
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30 eyes of 28 patients (26 males and 2 females) with a mean age of 25+/- 6.8 years (12-49) were enrolled in study. Corneal epithelial defect healed within 74.41+/- 48.07 days(22-180 days) in the amniotic membrane group versus 99.67+/- 36.8(56- 170 days) in controls(p=0.163). Perilimbal ischemia improved in 76.41+/-42.8 days in the amniotic membrane group versus 89.16+/-44.6 days in the control group (p=0.482). Mean final visual acuity was 0.024+/- 0.655logMAR versus -0.072+/- 0.5logMAR in the amniotic membrane and control groups, respectively (p=0.655). In the amniotic membrane group, symblepharon developed in 6 eyes versus 10 eyes in the control group. Totally 3 eyes developed corneal perforation whom undergone tectonic corneal graft.
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Conclusion:
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Compared to conventional medical therapy, combined AMT and medical therapy does not improve perilimbal ischemia or accelerate corneal epithelization. It also does not decrease corneal vascularization or improve visual acuity.
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Attachment:
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