To report a case of Gardner Syndrome with orbital, gasrointestinal and mandibular manifestations.

A 24-year-old man presented with a palpable mass in the deep superonasal quadrant of the left orbit which had been present for one year. He had no visual complaints, yet noted multiple hard masses at the right and left mandibular angles. The patient had history of a similar mass in his right orbit which had prompted surgical intervention 2 years earlier. Histopathological evaluation of the right orbital mass had revealed an osteoma.

Computed tomography (CT) displayed well-circumscribed masses with bone density consistent with osteomas in the right orbital region adjacent to the optic canal, and within the ethmoidal air cells, bilaterally (Fig. 3). Hyperdensity was observed in the left mandible on skull x-ray consistent with an osteoma (Fig. 4). A visual field test was performed to rule out defects caused by compressive optic neuropathy, which revealed to be normal.

adolescents and young adults with cranial osteomas or other features suspicious of Gardner syndrome are required to undergo colonoscopic studies; establishing a correct diagnosis by an ophthalmologist may lead to a life-saving intervention.