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مقاله
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Abstract
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Title:
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The Expression of Vascular Endothelial Growth Factor in Pterygium Tissue of Atopic Patients
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Author(s):
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Hamid Gharaee MD,Mohammad Reza Shayegan MD,Mohammad Reza Khakzad ,Sina Kianoush ,A-Reza Varasteh ,Mojtaba Sankian ,Mojtaba Meshkat
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Presentation Type:
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Poster
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamid Gharaee
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Affiliation :(optional)
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eye research center,Mashhad University of medical Sciences-Zakariya Research center,Mashhad Brunch,Slamic Azad University, Mashhad,IRAN
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E mail:
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gharaee_oph@yahoo.com
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Phone:
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8456918
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Mobile:
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09151117976
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Purpose:
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The aim of this study was to compare the association between pterygium and VEGF gene expression between atopic and non-atopic individuals.
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Methods:
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At first visit, all patients with pterygium underwent blood tests, serum IgE, serum cytokines including Interleukin (IL-4) and interferon-γ (IFN-γ) and peripheral blood eosinophil count. Skin prick test was performed to confirm or rule out atopy in 30 patients with (case group) and 30 patients without (control group) atopy. Then pterygium tissues were removed by surgery. A semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was performed to determine VEGF gene expression in all patients.
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Results:
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VEGF mRNA expression in atopic patients were significantly higher than non-atopic group (1.90 ± 0.74 vs. 1.44 ± 0.52, P-value = 0.01). Eosinophil count, serum IgE and IL-4 were also significantly higher in atopic patients compared to the non-atopic group (P = 0.03, 0.001 and 0.001, respectively). However, no significant difference was noted in serum IFN-γ between two groups (P = 0.06).
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Conclusion:
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The excessive expression of VEGF gene in pterygium tissue of patients with atopy suggests that growth factors may play a role in the pathogenesis of pterygium or accelerate its formation.
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Attachment:
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633.pptx
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