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مقاله
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Abstract
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Title:
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Lacritin Level in Tear Film of Rheumatoid Arthritis Patients
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Author(s):
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Rana Sorkhabi, mohammad hosein ahour, Mehrnoosh Ghasemi
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Rana Daei sorkhabi
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Affiliation :(optional)
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associate prof. of ophthalmology.Tabriz University of Medical Sciences
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E mail:
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sorkhabi_r@yahoo.com
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Phone:
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4770545
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Mobile:
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09134153771
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Purpose:
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The main ocular manifestation of rheumatoid arthritis is dry eyes. Lacritin is a secreted glycoprotein of tear and when applied topically in rabbits, it increased the volume of basal tear secretion. So the aim of this study was to compare Lacritin level in rheumatoid arthritis (RA) and control group.
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Methods:
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This cross-sectional study was done on 40 patients with RA and 48 healthy subjects as a control group. In all participants, tear break- up time (TBUT) and Schirmer test with anesthesia were accomplished. Tear samples were collected directly from the inferior lateral tear meniscus and were immediately stored at -80oc until use. Lacritin level of tears were assessed by enzyme- linked immunosorbent assay.
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Results:
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This cross-sectional study was done on 40 patients with RA and 48 healthy subjects as a control group. In all participants, tear break- up time (TBUT) and Schirmer test with anesthesia were accomplished. Tear samples were collected directly from the inferior lateral tear meniscus and were immediately stored at -80oc until use. Lacritin level of tears were assessed by enzyme- linked immunosorbent assay.
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Conclusion:
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In early stages of rheumatoid arthritis in spite of normal tear production, Lacritin level decreased , however there is not any correlation between Lacritin level and TBUT , Schirmer value , ESR, and hsCRP in these patients.
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Attachment:
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