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مقاله
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Abstract
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Title:
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Early initiation of aqueous suppressants, Timolol - Trusopt fixed combination, on Ahmed Glaucoma valve implantation outcome
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Author(s):
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Mohammad Pakravan1, MD; Shahram Salehi Rad1 MD; Shahin Yazdani1, MD; Elaham Ghahari 1, MD; Mehdi Yaseri2, PHD.
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Presentation Type:
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Oral
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Subject:
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Glaucoma
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Others:
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Presenting Author:
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Name:
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Mohammad Pakravan
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Affiliation :(optional)
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1 Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences 2 Department of Epidemiology and Biostatics, School of Public Health, Tehran University of Medical Sciences
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E mail:
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mopakravan@yahoo.com
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Phone:
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22560032
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Mobile:
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09121433478
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Purpose:
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To evaluate the effect of early aqueous suppressants initiation on Ahmed glaucoma valve (AGV) implantation outcome.
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Methods:
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In this randomized clinical trial, 94 eyes of 94 patients with refractory glaucoma were enrolled and assigned into 2 groups. After AGV implantation, group 1 (case; n=47) received topical Timolol-Dorzolamide fixed combination twice daily when the intraocular pressure (IOP) reached 10 mmHg, and group 2 (control; n=47) received stepwise glaucoma medications when IOP reached higher than target. Main outcome measures included IOP and success rate (defined as 6 < IOP <15 mmHg and at least 30% IOP reduction). Other outcome measures included, best corrected visual acuity (BCVA), complications, and rate of hypertensive phase.
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Results:
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forty seven eyes in group 1 and 2 were followed for a mean period of 45 ± 11.6 and 47.2 ± 7.4 weeks respectively (P= 0.74). Using mixed model analysis the IOP reduction was significantly more in group 1 at all interval points (p<0.001). Success rate was significantly higher in group 1 (63.2% versus 33.3%, P= 0.008). The rate of hypertensive phase was significantly more in control group (23.4% versus 66.0%, P<0.001).
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Conclusion:
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Early initiation of aqueous suppressants may improve success rate of AGV implantation, and can be considered in postoperative management of this procedure.
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Attachment:
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